COL6A1

Across TCGA patient cohorts, COL6A1 mutation is significantly associated with the total protein of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COL6A1-associated genes across cancer lineages are Di-Ras3, 4E-BP1, and eEF2. Each is linked with COL6A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both COL6A1-to-partner and partner-to-COL6A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Di-Ras3 grouped by COL6A1-low versus COL6A1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL6A1→partner) and Y-score (partner→COL6A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Di-Ras3 →	-0.214	-3.000	.006	.034	3	3
UCEC	4E-BP1 →	+0.306	+2.584	<.001	<.001	3	3
COAD	eEF2 →	+0.298	+3.169	.012	.018	3	2
COAD	eIF4E →	+0.198	+3.012	.006	.018	3	2
COAD	GAPDH →	+0.443	+2.008	.031	.018	3	2
COAD	INPP4B →	-0.497	-2.691	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

Di-Ras3 by COL6A1 expression — COAD

Explore this box plot interactively →