COL6A1

Across TCGA cell cohorts, COL6A1 mutation is significantly associated with the RNA expression of many other genes, with 711 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible COL6A1-associated genes across cancer lineages are OR2B2, PTH2, and PNLIPRP1. Each is linked with COL6A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both COL6A1-to-partner and partner-to-COL6A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2B2 grouped by COL6A1-low versus COL6A1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL6A1→partner) and Y-score (partner→COL6A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR2B2 →	+0.062	+3.824	<.001	.002	3	2
LUNG_NSCLC_LUAD	PTH2 →	+0.235	+4.481	<.001	.001	3	2
CNS	PNLIPRP1 →	+0.293	+4.321	<.001	.009	3	2
BLOOD_Leukemia	CCDC42 →	+0.294	+3.615	<.001	.004	3	2
BLOOD_Lymphoma	KLHL40 →	+0.008	+4.209	<.001	.001	3	2
OVARY	ZNF705D →	+0.031	+2.832	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 711 associations by consensus.

OR2B2 by COL6A1 expression — LUNG_SCLC

Explore this box plot interactively →