COL5A3

Across TCGA pan-cancer cohorts, COL5A3 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated COL5A3 data layer compared with 25 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher COL5A3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated COL5A3 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

BLCA, UCEC, and KIRC are the cancer types where COL5A3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	IV	0.239	0.604	<.001	39	view →
UCEC	DFS	Median	All	0.960	0.824	.006	16	view →
KIRC	OS	Median	II,III,IV	0.170	0.696	.024	12	view →
LUSC	OS	Median	II,III,IV	0.179	0.687	.004	10	view →
PRAD	DFS	Median	All	0.160	0.888	<.001	8	view →
READ	DFS	Median	IV	0.255	0.628	.020	3	view →
HNSC	OS	Median	IV	1.000	0.698	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

COL5A3–BLCA (OS)

Open the BLCA breakdown →