COL5A3

Across TCGA pan-cancer cohorts, COL5A3 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of COL5A3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where COL5A3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types COL5A3 is over-expressed in tumor, although a few such as UCEC show the opposite, repressed pattern.

KIRC, HNSC, and COAD are the cancer types where COL5A3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in COL5A3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	+2.978	<.001	12	view →
HNSC	Female	IV	+2.906	<.001	12	view →
COAD	Male	II,III,IV	+1.323	<.001	11	view →
STAD	Male	II,III,IV	+1.690	<.001	7	view →
LIHC	Male	All	+1.675	<.001	7	view →
BLCA	All	All	+0.865	.011	6	view →
LUAD	All	II,III,IV	+0.805	.002	6	view →
READ	Male	All	+3.003	.009	4	view →
LUSC	All	II,III,IV	+1.424	<.001	4	view →
BRCA	Female	II,III,IV	+0.414	.010	4	view →
KICH	All	II,III,IV	+0.758	.010	2	view →
UCEC	All	All	−0.750	.015	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

COL5A3–KIRC

Open the KIRC breakdown →