COL5A3

Across TCGA pan-cancer cohorts, COL5A3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated COL5A3 data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher COL5A3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated COL5A3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

PDAC, HNSC, and LUAD are the cancer types where COL5A3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	All	0.282	0.571	.003	32	view →
HNSC	DFS	Median	All	0.976	0.908	.007	11	view →
LUAD	OS	Quartile	All	0.766	0.961	.014	9	view →
CCRCC	OS	Quartile	All	0.951	0.747	.021	2	view →
LSCC	DFS	Tertile	All	0.843	0.990	.025	1	view →
GBM	OS	Tertile	All	0.754	0.879	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

COL5A3–PDAC (DFS)

Open the PDAC breakdown →