COL5A3

Across TCGA patient cohorts, COL5A3 mutation is significantly associated with the RNA expression of many other genes, with 8,138 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible COL5A3-associated genes across cancer lineages are SLC2A13, RFC5, and MRPL3. Each is linked with COL5A3 in more than 4 cancer types. Because this analysis shows association rather than direction, both COL5A3-to-partner and partner-to-COL5A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC2A13 grouped by COL5A3-low versus COL5A3-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL5A3→partner) and Y-score (partner→COL5A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SLC2A13 →	+0.619	+1.930	<.001	.009	3	5
LUAD	RFC5 →	+0.518	+3.333	.001	.005	3	5
LUAD	MRPL3 →	+0.425	+1.954	.001	.009	3	5
UCEC	TAF13 →	+0.402	+1.482	.002	.003	3	5
SKCM	PDIK1L →	+0.328	+1.120	.001	.003	3	5
UCEC	GNPNAT1 →	+0.643	+1.555	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,138 associations by consensus.

SLC2A13 by COL5A3 expression — LUAD

Explore this box plot interactively →