COL5A3

Across TCGA patient cohorts, COL5A3 mutation is significantly associated with the total protein of many other genes, with 68 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COL5A3-associated genes across cancer lineages are Caspase-7-cleavedD198, GAPDH, and ER-alpha_pS118. Each is linked with COL5A3 in more than 3 cancer types. Because this analysis shows association rather than direction, both COL5A3-to-partner and partner-to-COL5A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by COL5A3-low versus COL5A3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL5A3→partner) and Y-score (partner→COL5A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.570	+2.090	<.001	<.001	3	4
BLCA	GAPDH →	+0.534	+3.906	.003	<.001	3	3
STAD	ER-alpha_pS118 →	+0.101	+3.584	.006	.002	3	3
SKCM	Stathmin →	+0.088	+0.918	.047	.036	3	3
SKCM	ASNS →	+0.267	+1.184	.012	.017	3	3
UCEC	eEF2 →	+0.296	+1.536	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 68 associations by consensus.

Caspase-7-cleavedD198 by COL5A3 expression — UCEC

Explore this box plot interactively →