COL5A3

Across TCGA cell cohorts, COL5A3 mutation is significantly associated with the RNA expression of many other genes, with 874 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible COL5A3-associated genes across cancer lineages are AADACL2, MPC1L, and FGF3. Each is linked with COL5A3 in more than 2 cancer types. Because this analysis shows association rather than direction, both COL5A3-to-partner and partner-to-COL5A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AADACL2 grouped by COL5A3-low versus COL5A3-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL5A3→partner) and Y-score (partner→COL5A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	AADACL2 →	+0.023	+5.000	<.001	.005	3	3
BLOOD_Lymphoma	MPC1L →	+0.042	+3.606	<.001	.002	3	2
OVARY	FGF3 →	+0.017	+3.095	.007	.009	3	2
SKIN	WDR87 →	+0.010	+1.773	<.001	.009	3	2
SKIN	OR51E1 →	+0.009	+2.156	.004	<.001	3	2
LARGE_INTESTINE	GCFC2 →	+0.555	+2.265	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 874 associations by consensus.

AADACL2 by COL5A3 expression — KIDNEY

Explore this box plot interactively →