COL5A3

Across TCGA cell cohorts, COL5A3 mutation is significantly associated with the mutation status of many other genes, with 6,532 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible COL5A3-associated genes across cancer lineages are CDH26, RP1, and LRRK2. Each is linked with COL5A3 in more than 4 cancer types. Because this analysis shows association rather than direction, both COL5A3-to-partner and partner-to-COL5A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDH26 grouped by COL5A3-low versus COL5A3-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL5A3→partner) and Y-score (partner→COL5A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CDH26 →	+5.115	+5.115	.005	.005	1	5
BLOOD_Leukemia	RP1 →	+3.037	+2.382	<.001	<.001	1	5
BLOOD_Leukemia	LRRK2 →	+3.037	+2.695	<.001	<.001	1	5
LARGE_INTESTINE	NALCN →	+2.237	+2.237	<.001	<.001	1	5
LARGE_INTESTINE	ABCG5 →	+4.584	+2.485	<.001	<.001	1	5
LUNG_NSCLC_LUAD	DNAH6 →	+2.192	+3.896	.006	.006	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,532 associations by consensus.

CDH26 by COL5A3 expression — PANCREAS

Explore this box plot interactively →