Across TCGA pan-cancer cohorts, COL4A6 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of COL4A6’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where COL4A6 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types COL4A6 is over-expressed in tumor, although a few such as COAD and CCRCC show the opposite, repressed pattern.

COAD, CCRCC, and HNSC are the cancer types where COL4A6 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in COL4A6 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	−1.654	<.001	10	view →
CCRCC	All	IV	−1.111	<.001	9	view →
HNSC	All	All	+0.591	.002	4	view →
LSCC	All	All	+0.552	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: COL4A6 RNA expression & survival · all COL4A6 data types