Across TCGA patient cohorts, COL4A6 protein abundance is significantly associated with the RNA expression of many other genes, with 1,538 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible COL4A6-associated genes across cancer lineages are KIF7, COL4A5, and GJB4. Each is linked with COL4A6 in more than 1 cancer types. Because this analysis shows association rather than direction, both COL4A6-to-partner and partner-to-COL4A6 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL4A6→partner) and Y-score (partner→COL4A6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	KIF7 →	+0.732	+1.014	<.001	<.001	3	2
LSCC	COL4A5 →	+1.468	+0.953	<.001	<.001	3	2
HNSC	GJB4 →	+1.302	+0.622	<.001	.002	3	2
HNSC	LINC02160 →	+1.846	+0.899	.002	.001	3	2
CCRCC	THSD1 →	+0.842	+0.839	.005	<.001	3	2
UCEC	IGFBP7 →	+0.940	+0.500	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,538 associations by consensus.

Exploration

COL4A6 survival (RNA) · tumor vs normal (RNA) · all COL4A6 data types