Across TCGA patient cohorts, COL4A6 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COL4A6-associated genes across cancer lineages are TAZ, 4E-BP1_pS65, and INPP4B. Each is linked with COL4A6 in more than 3 cancer types. Because this analysis shows association rather than direction, both COL4A6-to-partner and partner-to-COL4A6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL4A6→partner) and Y-score (partner→COL4A6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TAZ →	-0.148	-2.222	.021	.010	3	3
COAD	4E-BP1_pS65 →	+0.257	+3.182	.024	.009	2	4
UCEC	INPP4B →	-0.176	-1.874	.039	.001	3	3
UCEC	TFRC →	+0.387	+1.280	.005	.049	3	3
LUAD	Heregulin →	-0.140	-3.459	.012	.005	3	2
LUAD	MSH6 →	+0.278	+3.186	.020	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

Exploration

COL4A6 survival (RNA) · tumor vs normal (RNA) · all COL4A6 data types