Across TCGA cell cohorts, COL4A6 mutation is significantly associated with the RNA expression of many other genes, with 551 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible COL4A6-associated genes across cancer lineages are PNLIP, KRTAP21-2, and FAM136A. Each is linked with COL4A6 in more than 1 cancer types. Because this analysis shows association rather than direction, both COL4A6-to-partner and partner-to-COL4A6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL4A6→partner) and Y-score (partner→COL4A6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PNLIP →	+0.039	+3.990	<.001	.003	3	2
LUNG_NSCLC_LUAD	KRTAP21-2 →	+0.123	+2.343	<.001	.008	3	2
LARGE_INTESTINE	FAM136A →	+0.594	+3.364	<.001	.002	3	2
PANCREAS	ELSPBP1 →	+0.040	+5.000	.003	.006	3	1
PANCREAS	C7orf33 →	+0.033	+5.614	<.001	.002	3	1
PANCREAS	CD300E →	+0.013	+5.000	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 551 associations by consensus.

Exploration

COL4A6 survival (RNA) · tumor vs normal (RNA) · all COL4A6 data types