COL4A3

Across TCGA patient cohorts, COL4A3 mutation is significantly associated with the RNA expression of many other genes, with 6,707 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COL4A3-associated genes across cancer lineages are BUB3, MAD2L1, and FBXO22. Each is linked with COL4A3 in more than 4 cancer types. Because this analysis shows association rather than direction, both COL4A3-to-partner and partner-to-COL4A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BUB3 grouped by COL4A3-low versus COL4A3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL4A3→partner) and Y-score (partner→COL4A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BUB3 →	+0.497	+1.378	<.001	<.001	3	5
UCEC	MAD2L1 →	+0.650	+1.828	<.001	<.001	3	5
UCEC	FBXO22 →	+0.500	+1.999	<.001	<.001	3	5
UCEC	TIPIN →	+0.543	+1.988	<.001	<.001	3	5
UCEC	MCAT →	+0.403	+2.627	<.001	<.001	3	5
UCEC	ITPK1 →	+0.341	+1.971	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,707 associations by consensus.

BUB3 by COL4A3 expression — UCEC

Explore this box plot interactively →