COL4A3

Across TCGA pan-cancer cohorts, COL4A3 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated COL4A3 data layer compared with 5 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher COL4A3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated COL4A3 expression acts as an unfavorable survival marker, although some lineages such as ACC and SKCM show a favorable association.

UCEC, ACC, and SKCM are the cancer types where COL4A3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	All	0.542	0.748	<.001	112	view →
ACC	DFS	Quartile	All	0.627	0.210	.001	79	view →
SKCM	OS	Median	II,III,IV	0.804	0.659	<.001	72	view →
LUAD	OS	Quartile	All	0.813	0.602	<.001	53	view →
KIRC	OS	Tertile	All	0.712	0.541	<.001	51	view →
LUSC	DFS	Tertile	All	0.286	0.466	.002	47	view →
CHOL	OS	Median	All	0.960	0.558	.003	31	view →
KIRP	DFS	Tertile	II,III,IV	0.189	0.689	.001	29	view →
LIHC	OS	Median	III,IV	0.741	0.545	.006	24	view →
UVM	OS	Tertile	III,IV	0.271	1.000	.016	23	view →
HNSC	DFS	Median	IV	0.394	0.259	.013	18	view →
READ	OS	Median	III,IV	0.833	0.296	.004	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

COL4A3–UCEC (DFS)

Open the UCEC breakdown →