COL4A3

Across TCGA cell cohorts, COL4A3 mutation is significantly associated with the RNA expression of many other genes, with 123 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible COL4A3-associated genes across cancer lineages are UGT3A1, S100G, and RFPL3. Each is linked with COL4A3 in more than 1 cancer types. Because this analysis shows association rather than direction, both COL4A3-to-partner and partner-to-COL4A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UGT3A1 grouped by COL4A3-low versus COL4A3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL4A3→partner) and Y-score (partner→COL4A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	UGT3A1 →	+0.104	+3.485	<.001	.009	3	2
BREAST	S100G →	+0.300	+3.378	.001	<.001	3	2
LUNG_NSCLC_LUAD	RFPL3 →	+0.059	+3.605	.004	.007	3	2
BONE	ZNF683 →	+0.033	+5.169	<.001	.004	3	1
OESOPHAGUS	SLC10A2 →	+0.006	+4.906	<.001	.006	3	1
OESOPHAGUS	NLRP8 →	+0.006	+4.906	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 123 associations by consensus.

UGT3A1 by COL4A3 expression — BLOOD_Leukemia

Explore this box plot interactively →