COL4A2-AS1

Across TCGA pan-cancer cohorts, COL4A2-AS1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of COL4A2-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where COL4A2-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types COL4A2-AS1 is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

THCA, BRCA, and LUAD are the cancer types where COL4A2-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in COL4A2-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.654	<.001	11	view →
BRCA	All	IV	−1.170	<.001	8	view →
LUAD	All	II,III,IV	−0.546	<.001	8	view →
BLCA	All	All	−0.432	.001	8	view →
HNSC	All	III,IV	+0.180	.001	8	view →
KICH	All	All	−0.285	.001	7	view →
LUSC	Female	All	−0.826	<.001	6	view →
KIRP	Male	All	−0.406	.001	4	view →
KIRC	Female	All	+0.402	<.001	4	view →
CHOL	All	All	+0.618	<.001	3	view →
LIHC	All	II,III,IV	+0.094	.037	3	view →
UCEC	All	All	−0.396	.028	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

COL4A2-AS1–THCA

Open the THCA breakdown →