COL2A1

Across TCGA pan-cancer cohorts, COL2A1 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of COL2A1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where COL2A1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types COL2A1 is over-expressed in tumor, although a few such as COAD and HNSC show the opposite, repressed pattern.

COAD, HNSC, and CCRCC are the cancer types where COL2A1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in COL2A1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	−1.539	<.001	9	view →
HNSC	Male	III,IV	−1.657	<.001	8	view →
CCRCC	Female	All	+0.370	.011	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

COL2A1–COAD

Open the COAD breakdown →