COL2A1

Across TCGA cell cohorts, COL2A1 mutation is significantly associated with the RNA expression of many other genes, with 751 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible COL2A1-associated genes across cancer lineages are PRIMPOL, TK2, and HDHD2. Each is linked with COL2A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both COL2A1-to-partner and partner-to-COL2A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRIMPOL grouped by COL2A1-low versus COL2A1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL2A1→partner) and Y-score (partner→COL2A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PRIMPOL →	+0.540	+2.265	.001	.001	3	2
LARGE_INTESTINE	TK2 →	+0.740	+2.584	<.001	.002	3	2
LARGE_INTESTINE	HDHD2 →	+0.693	+2.546	.001	.001	3	2
LARGE_INTESTINE	KIFC2 →	+1.000	+3.459	<.001	<.001	3	2
LARGE_INTESTINE	PPP5D1 →	+0.265	+2.716	<.001	<.001	3	2
BLOOD_Lymphoma	MMP26 →	+0.089	+4.643	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 751 associations by consensus.

PRIMPOL by COL2A1 expression — LARGE_INTESTINE

Explore this box plot interactively →