COL26A1

Across TCGA patient cohorts, COL26A1 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COL26A1-associated genes across cancer lineages are C-Raf, Cyclin-B1, and Di-Ras3. Each is linked with COL26A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both COL26A1-to-partner and partner-to-COL26A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by COL26A1-low versus COL26A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL26A1→partner) and Y-score (partner→COL26A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.229	+3.321	<.001	.010	3	2
UCEC	Cyclin-B1 →	+0.777	+2.459	.004	.020	3	2
UCEC	Di-Ras3 →	-0.286	-3.156	<.001	.018	3	2
UCEC	14-3-3_beta →	-0.148	-2.446	.002	.020	3	1
UCEC	EGFR_pY1068 →	-0.417	-3.169	<.001	.019	3	1
UCEC	ERK2 →	+0.240	+2.999	.010	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

C-Raf by COL26A1 expression — UCEC

Explore this box plot interactively →