COL25A1-DT

Across TCGA pan-cancer cohorts, COL25A1-DT RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated COL25A1-DT data layer.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher COL25A1-DT RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated COL25A1-DT expression acts as an unfavorable survival marker, although some lineages such as UCS and MESO show a favorable association.

UCS, MESO, and ESCA are the cancer types where COL25A1-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Median	II,III,IV	0.569	0.144	.001	114	view →
MESO	OS	Median	All	0.704	0.393	<.001	72	view →
ESCA	OS	Tertile	IV	0.127	0.571	.003	36	view →
BLCA	OS	Tertile	II,III,IV	0.561	0.403	.015	33	view →
UCEC	OS	Median	All	0.902	0.936	.004	30	view →
UVM	OS	Quartile	All	0.756	1.000	.021	22	view →
CHOL	OS	Tertile	II,III,IV	1.000	0.473	.020	21	view →
LUAD	DFS	Quartile	II,III,IV	0.549	0.798	.002	21	view →
THYM	OS	Tertile	II,III,IV	0.848	1.000	.005	20	view →
LUSC	OS	Tertile	IV	0.001	0.651	.025	18	view →
SKCM	OS	Quartile	II,III,IV	0.199	0.358	.022	16	view →
KICH	OS	Tertile	All	0.913	0.972	.025	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

COL25A1-DT–UCS (DFS)

Open the UCS breakdown →