COL25A1-DT

Across TCGA pan-cancer cohorts, COL25A1-DT RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of COL25A1-DT’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where COL25A1-DT RNA is repressed in tumor relative to normal tissue. In most cancer types COL25A1-DT is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

THCA, BRCA, and COAD are the cancer types where COL25A1-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in COL25A1-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	II,III,IV	−0.115	<.001	8	view →
BRCA	All	III,IV	−0.107	<.001	6	view →
COAD	All	III,IV	−0.023	.012	2	view →
READ	All	All	−0.022	.020	2	view →
LUAD	All	All	+0.040	.047	1	view →
LUSC	Male	II,III,IV	−0.027	.046	1	view →
KIRC	Male	All	+0.024	.015	1	view →
STAD	Male	All	−0.009	.012	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

COL25A1-DT–THCA

Open the THCA breakdown →