COL21A1

Across TCGA patient cohorts, COL21A1 mutation is significantly associated with the RNA expression of many other genes, with 3,660 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COL21A1-associated genes across cancer lineages are RNU6-391P, SKA1, and PKN3. Each is linked with COL21A1 in more than 3 cancer types. Because this analysis shows association rather than direction, both COL21A1-to-partner and partner-to-COL21A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-391P grouped by COL21A1-low versus COL21A1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL21A1→partner) and Y-score (partner→COL21A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU6-391P →	+0.331	+7.731	<.001	.009	3	4
COAD	SKA1 →	+0.701	+3.196	.001	.009	3	3
UCEC	PKN3 →	+0.735	+1.868	<.001	<.001	3	3
UCEC	SCNN1B →	-1.315	-1.432	<.001	.005	3	3
COAD	TIMM21 →	+0.451	+3.196	.005	.009	3	3
UCEC	CDCA2 →	+0.576	+1.684	.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,660 associations by consensus.

RNU6-391P by COL21A1 expression — BRCA

Explore this box plot interactively →