COL1A2

Across TCGA patient cohorts, COL1A2 mutation is significantly associated with the total protein of many other genes, with 61 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COL1A2-associated genes across cancer lineages are Cyclin-B1, eEF2, and eIF4E. Each is linked with COL1A2 in more than 4 cancer types. Because this analysis shows association rather than direction, both COL1A2-to-partner and partner-to-COL1A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by COL1A2-low versus COL1A2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL1A2→partner) and Y-score (partner→COL1A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.588	+2.662	<.001	<.001	3	5
COAD	eEF2 →	+0.312	+2.356	.004	.017	3	4
STAD	eIF4E →	+0.183	+2.700	.012	.005	3	3
UCEC	ATM →	-0.571	-2.571	<.001	<.001	3	3
SKCM	Chk1 →	+0.125	+1.412	.029	.004	3	3
COAD	MIG-6 →	+0.075	+1.887	.041	.029	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

Cyclin-B1 by COL1A2 expression — UCEC

Explore this box plot interactively →