COL1A2

Across TCGA pan-cancer cohorts, COL1A2 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated COL1A2 data layer compared with 11 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher COL1A2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated COL1A2 expression acts as an unfavorable survival marker, although some lineages such as UCS and DLBC show a favorable association.

KIRP, MESO, and BLCA are the cancer types where COL1A2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.537	0.821	<.001	128	view →
MESO	OS	Median	II,III,IV	0.282	0.503	<.001	93	view →
BLCA	OS	Tertile	All	0.525	0.693	.001	74	view →
UCS	DFS	Median	II,III,IV	0.433	0.165	.013	60	view →
LGG	OS	Median	All	0.730	0.893	<.001	54	view →
ACC	OS	Median	II,III,IV	0.743	0.956	.001	40	view →
UVM	DFS	Quartile	All	0.359	0.835	.007	33	view →
CESC	DFS	Quartile	All	0.692	0.862	.001	32	view →
LUAD	OS	Quartile	All	0.758	0.860	.006	32	view →
DLBC	DFS	Median	III,IV	1.000	0.457	.003	31	view →
OV	DFS	Tertile	II,III,IV	0.480	0.594	.006	28	view →
KICH	DFS	Median	All	0.688	0.969	.001	27	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

COL1A2–KIRP (OS)

Open the KIRP breakdown →