COL17A1

Across TCGA patient cohorts, COL17A1 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COL17A1-associated genes across cancer lineages are mTOR_pS2448, MYH11, and cIAP. Each is linked with COL17A1 in more than 3 cancer types. Because this analysis shows association rather than direction, both COL17A1-to-partner and partner-to-COL17A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by COL17A1-low versus COL17A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL17A1→partner) and Y-score (partner→COL17A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.105	-1.723	.009	.005	3	4
STAD	MYH11 →	-1.359	-2.321	.042	.034	3	3
SKCM	cIAP →	+0.112	+1.726	.022	.023	3	3
SKCM	E-Cadherin →	-0.663	-1.584	.023	.032	3	3
UCEC	ASNS →	+0.335	+1.201	<.001	.025	3	3
LUAD	Di-Ras3 →	-0.099	-2.321	.035	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

mTOR_pS2448 by COL17A1 expression — UCEC

Explore this box plot interactively →