COL17A1

Across TCGA cell cohorts, COL17A1 mutation is significantly associated with the RNA expression of many other genes, with 1,292 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible COL17A1-associated genes across cancer lineages are OR4F5, IFNA2, and MAGEB1. Each is linked with COL17A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both COL17A1-to-partner and partner-to-COL17A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4F5 grouped by COL17A1-low versus COL17A1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL17A1→partner) and Y-score (partner→COL17A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR4F5 →	+0.005	+3.029	<.001	.003	3	2
BLOOD_Leukemia	IFNA2 →	+0.617	+3.536	<.001	.001	3	2
LUNG_SCLC	MAGEB1 →	+1.163	+3.932	.005	<.001	3	2
LUNG_SCLC	CEBPE →	+0.055	+2.736	.001	.002	3	2
BLOOD_Leukemia	SPIC →	+0.825	+4.099	<.001	<.001	3	2
LARGE_INTESTINE	OCIAD1 →	+0.489	+2.850	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,292 associations by consensus.

OR4F5 by COL17A1 expression — LUNG_SCLC

Explore this box plot interactively →