Across TCGA patient cohorts, COL11A2 mutation is significantly associated with the RNA expression of many other genes, with 5,725 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COL11A2-associated genes across cancer lineages are FANCE, NDUFC1, and MRPL37. Each is linked with COL11A2 in more than 4 cancer types. Because this analysis shows association rather than direction, both COL11A2-to-partner and partner-to-COL11A2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL11A2→partner) and Y-score (partner→COL11A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	FANCE →	+0.783	+2.596	<.001	.006	3	5
UCEC	NDUFC1 →	+0.317	+1.731	<.001	<.001	3	4
UCEC	MRPL37 →	+0.517	+2.772	<.001	<.001	3	4
UCEC	HROB →	+0.609	+2.536	<.001	<.001	3	4
SKCM	SMYD5 →	+0.226	+1.841	.001	<.001	3	4
STAD	PBK →	+1.056	+3.182	.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,725 associations by consensus.

Exploration

COL11A2 survival (RNA) · tumor vs normal (RNA) · all COL11A2 data types