Across TCGA pan-cancer cohorts, COL11A2 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of COL11A2’s most consistent transcriptional readouts.
The strongest signal is observed in kidney chromophobe (KICH), where COL11A2 RNA is repressed in tumor relative to normal tissue. In most cancer types COL11A2 is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.
KICH, BRCA, and UCEC are the cancer types where COL11A2 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in COL11A2 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.