COL11A1

Across TCGA pan-cancer cohorts, COL11A1 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of COL11A1’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where COL11A1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types COL11A1 is over-expressed in tumor.

PDAC, LUAD, and LSCC are the cancer types where COL11A1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in COL11A1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Female	II,III,IV	+1.490	<.001	9	view →
LUAD	All	III,IV	+1.181	<.001	9	view →
LSCC	Male	II,III,IV	+1.564	<.001	8	view →
HNSC	Male	IV	+1.125	<.001	8	view →
COAD	Male	II,III,IV	+0.549	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

COL11A1–PDAC

Open the PDAC breakdown →