COL11A1

Across TCGA pan-cancer cohorts, COL11A1 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated COL11A1 data layer compared with 10 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher COL11A1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated COL11A1 expression acts as an unfavorable survival marker, although some lineages such as UVM and DLBC show a favorable association.

UVM, KIRP, and MESO are the cancer types where COL11A1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.735	0.401	<.001	128	view →
KIRP	DFS	Median	All	0.782	0.922	<.001	119	view →
MESO	DFS	Median	All	0.279	0.500	<.001	105	view →
ACC	DFS	Tertile	All	0.441	0.799	<.001	95	view →
KIRC	DFS	Tertile	All	0.532	0.710	<.001	89	view →
CESC	DFS	Tertile	All	0.750	0.894	<.001	60	view →
LUAD	OS	Tertile	All	0.312	0.478	.001	43	view →
LGG	DFS	Median	All	0.330	0.479	<.001	41	view →
BLCA	DFS	Quartile	All	0.563	0.711	.004	26	view →
STAD	OS	Quartile	II,III,IV	0.310	0.602	.010	22	view →
UCEC	DFS	Quartile	All	0.578	0.702	.002	18	view →
OV	DFS	Median	All	0.495	0.586	.015	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

COL11A1–UVM (DFS)

Open the UVM breakdown →