COL11A1

Across TCGA patient cohorts, COL11A1 mutation is significantly associated with the total protein of many other genes, with 115 significant associations in total. STAD shows the largest number of these associations.

The most reproducible COL11A1-associated genes across cancer lineages are Caspase-7-cleavedD198, mTOR_pS2448, and MYH11. Each is linked with COL11A1 in more than 6 cancer types. Because this analysis shows association rather than direction, both COL11A1-to-partner and partner-to-COL11A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by COL11A1-low versus COL11A1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL11A1→partner) and Y-score (partner→COL11A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.007	+2.745	<.001	<.001	3	7
HNSC	mTOR_pS2448 →	-0.217	-2.321	.006	.030	3	4
STAD	MYH11 →	-1.234	-1.807	.006	.023	3	4
STAD	PCNA →	+0.278	+3.700	.001	<.001	3	4
STAD	4E-BP1 →	+0.372	+3.700	<.001	<.001	3	4
STAD	Cyclin-B1 →	+0.566	+2.584	<.001	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 115 associations by consensus.

Caspase-7-cleavedD198 by COL11A1 expression — COAD

Explore this box plot interactively →