COIL

Across TCGA patient cohorts, COIL protein abundance is significantly associated with the RNA expression of many other genes, with 16,400 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible COIL-associated genes across cancer lineages are MRPS7, NME1, and RAD51C. Each is linked with COIL in more than 8 cancer types. Because this analysis shows association rather than direction, both COIL-to-partner and partner-to-COIL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, COIL versus MRPS7 in UCEC, with a Pearson correlation of 0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COIL→partner) and Y-score (partner→COIL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MRPS7 →	+0.789	+0.281	<.001	.001	3	9
LUAD	NME1 →	+0.663	+0.233	<.001	<.001	3	9
OV	RAD51C →	+0.660	+0.317	.001	.001	3	8
BRCA	TRIM37 →	+0.741	+0.499	.001	<.001	3	8
GBM	HELLS →	+0.923	+0.319	<.001	<.001	3	8
BRCA	NUP85 →	+0.595	+0.455	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,400 associations by consensus.

COIL vs MRPS7 — UCEC

Explore this scatter interactively →