COIL

Across TCGA cell cohorts, COIL RNA expression is significantly associated with the go_rna of many other GO terms, with 3,707 significant associations in total. CNS shows the largest number of these associations.

The most reproducible COIL-associated GO terms across cancer lineages are Negative regulation of beige fat cell differentiation, snRNA processing, and Heterochromatin formation. Each is linked with COIL in more than 12 cancer types. Because this analysis shows association rather than direction, both COIL-to-partner and partner-to-COIL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of beige fat cell differentiation grouped by COIL-low versus COIL-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (COIL→partner) and Y-score (partner→COIL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Negative regulation of beige fat cell differentiation →	+0.110	+0.606	<.001	<.001	3	13
CNS	snRNA processing →	+0.063	+0.507	<.001	<.001	3	13
PANCREAS	Heterochromatin formation →	+0.065	+0.696	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	RNA splicing, via transesterification reactions →	+0.068	+0.629	.005	.003	2	13
STOMACH	Negative regulation of gene expression, epigenetic →	+0.067	+0.468	<.001	.007	2	13
SOFT_TISSUE	Double-strand break repair →	+0.062	+0.653	.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,707 associations by consensus.

Negative regulation of beige fat cell differentiation by COIL expression — BREAST

Explore this box plot interactively →