COIL

Across TCGA cell cohorts, COIL mutation is significantly associated with the RNA expression of many other genes, with 215 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible COIL-associated genes across cancer lineages are ADAM18, TRIM60, and XAGE5. Each is linked with COIL in more than 1 cancer types. Because this analysis shows association rather than direction, both COIL-to-partner and partner-to-COIL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAM18 grouped by COIL-low versus COIL-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COIL→partner) and Y-score (partner→COIL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ADAM18 →	+0.041	+4.269	<.001	.005	3	1
LUNG_SCLC	TRIM60 →	+0.005	+4.643	<.001	.004	3	1
OVARY	XAGE5 →	+0.255	+5.196	<.001	.005	3	1
LARGE_INTESTINE	ZBED4 →	+0.566	+3.137	.004	.007	3	1
LARGE_INTESTINE	DOT1L →	+0.827	+3.299	.004	.004	3	1
LARGE_INTESTINE	GPR63 →	+0.888	+3.212	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 215 associations by consensus.

ADAM18 by COIL expression — LUNG_SCLC

Explore this box plot interactively →