Across TCGA patient cohorts, COG8 mutation is significantly associated with the RNA expression of many other genes, with 429 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COG8-associated genes across cancer lineages are SFXN1, RNU6-391P, and OR7E111P. Each is linked with COG8 in more than 2 cancer types. Because this analysis shows association rather than direction, both COG8-to-partner and partner-to-COG8 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COG8→partner) and Y-score (partner→COG8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SFXN1 →	+0.754	+2.604	.007	.006	3	3
SKCM	RNU6-391P →	+0.095	+3.900	<.001	.008	3	3
BLCA	OR7E111P →	+0.089	+3.320	<.001	.008	3	3
HNSC	RNU6-1298P →	+0.358	+7.954	<.001	.008	3	2
CESC	DNMT3AP1 →	+0.030	+5.418	<.001	.005	3	2
UCEC	MIR6085 →	+0.409	+2.221	.006	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 429 associations by consensus.

Exploration

COG8 survival (RNA) · tumor vs normal (RNA) · all COG8 data types