COG6

Across TCGA cell cohorts, COG6 mutation is significantly associated with the RNA expression of many other genes, with 287 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible COG6-associated genes across cancer lineages are AVP, C18orf63, and DAO. Each is linked with COG6 in more than 1 cancer types. Because this analysis shows association rather than direction, both COG6-to-partner and partner-to-COG6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVP grouped by COG6-low versus COG6-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COG6→partner) and Y-score (partner→COG6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	AVP →	+0.031	+5.209	<.001	.005	3	2
BLOOD_Lymphoma	C18orf63 →	+0.012	+4.867	<.001	.009	3	1
BLOOD_Leukemia	DAO →	+0.042	+3.359	<.001	.002	3	1
BLOOD_Leukemia	C6orf118 →	+0.044	+3.772	<.001	<.001	3	1
BLOOD_Leukemia	SV2C →	+0.254	+3.956	<.001	.002	3	1
BLOOD_Leukemia	ACTRT1 →	+0.020	+3.786	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 287 associations by consensus.

AVP by COG6 expression — BLOOD_Lymphoma

Explore this box plot interactively →