COG5

Across TCGA pan-cancer cohorts, COG5 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated COG5 data layer compared with 27 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher COG5 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated COG5 expression acts as an unfavorable survival marker, although some lineages such as COAD and LUAD show a favorable association.

COAD, LSCC, and PDAC are the cancer types where COG5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	1.000	0.920	.014	66	view →
LSCC	DFS	Median	All	0.412	0.856	.004	11	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	9	view →
LUAD	OS	Median	III,IV	0.796	0.298	.019	8	view →
CCRCC	OS	Median	All	0.634	1.000	.004	6	view →
UCEC	DFS	Tertile	All	0.945	0.829	.034	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

COG5–COAD (DFS)

Open the COAD breakdown →