COG5

Across TCGA pan-cancer cohorts, COG5 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of COG5’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where COG5 RNA is repressed in tumor relative to normal tissue. In most cancer types COG5 is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

THCA, LIHC, and COAD are the cancer types where COG5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in COG5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.239	<.001	10	view →
LIHC	Female	II,III,IV	+1.158	<.001	9	view →
COAD	Male	All	+0.592	<.001	8	view →
KIRP	All	II,III,IV	+0.562	.005	8	view →
BRCA	All	II,III,IV	+0.322	<.001	8	view →
LUAD	Male	All	+0.697	<.001	7	view →
HNSC	All	III,IV	+0.441	.021	6	view →
CHOL	Male	All	+2.055	<.001	5	view →
ESCA	All	All	+0.662	.002	5	view →
LUSC	All	All	+0.433	<.001	5	view →
STAD	All	All	+0.363	.016	4	view →
UCEC	All	All	−0.474	.029	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

COG5–THCA

Open the THCA breakdown →