COG5

Across TCGA patient cohorts, COG5 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COG5-associated genes across cancer lineages are PCNA, JNK_pT183_Y185, and MIG-6. Each is linked with COG5 in more than 2 cancer types. Because this analysis shows association rather than direction, both COG5-to-partner and partner-to-COG5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by COG5-low versus COG5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COG5→partner) and Y-score (partner→COG5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.259	+2.459	<.001	<.001	3	3
UCEC	JNK_pT183_Y185 →	-0.170	-3.087	.003	<.001	3	2
UCEC	MIG-6 →	+0.080	+1.453	.020	.015	3	2
UCEC	p21 →	+0.162	+2.321	.015	.005	3	2
UCEC	PDCD4 →	-0.566	-2.492	<.001	.001	3	2
UCEC	TFRC →	+0.471	+1.440	.010	.024	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

PCNA by COG5 expression — UCEC

Explore this box plot interactively →