COG5

Across TCGA cell cohorts, COG5 mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible COG5-associated genes across cancer lineages are OR2D3, OR2H1, and MAGEB4. Each is linked with COG5 in more than 1 cancer types. Because this analysis shows association rather than direction, both COG5-to-partner and partner-to-COG5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2D3 grouped by COG5-low versus COG5-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COG5→partner) and Y-score (partner→COG5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OR2D3 →	+0.036	+4.990	<.001	.001	3	1
OVARY	OR2H1 →	+0.027	+4.029	<.001	.009	3	1
LARGE_INTESTINE	MAGEB4 →	+0.024	+6.000	<.001	<.001	3	1
LARGE_INTESTINE	STRA8 →	+0.161	+4.415	<.001	.007	3	1
LARGE_INTESTINE	ZNF804B →	+0.016	+4.415	<.001	.007	3	1
LARGE_INTESTINE	DAZ2 →	+0.252	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

OR2D3 by COG5 expression — OVARY

Explore this box plot interactively →