COG4

Across TCGA pan-cancer cohorts, COG4 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated COG4 data layer compared with 22 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher COG4 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated COG4 expression acts as an unfavorable survival marker, although some lineages such as UCEC and PDAC show a favorable association.

UCEC, LSCC, and CCRCC are the cancer types where COG4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	II,III,IV	1.000	0.298	<.001	50	view →
LSCC	DFS	Quartile	II,III,IV	0.374	0.835	.005	27	view →
CCRCC	DFS	Quartile	III,IV	0.268	0.883	<.001	17	view →
PDAC	DFS	Median	III,IV	0.505	0.247	.007	9	view →
LUAD	OS	Quartile	III,IV	0.879	0.315	.023	5	view →
GBM	OS	Median	All	0.523	0.256	.012	4	view →
HNSC	DFS	Median	III,IV	0.717	0.514	.023	4	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

COG4–UCEC (DFS)

Open the UCEC breakdown →