COG4

Across TCGA pan-cancer cohorts, COG4 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of COG4’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where COG4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types COG4 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

COAD, KIRP, and KICH are the cancer types where COG4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in COG4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	+0.567	<.001	10	view →
KIRP	All	II,III,IV	+0.561	<.001	10	view →
KICH	Female	II,III,IV	−1.034	<.001	9	view →
LIHC	Female	II,III,IV	+1.034	<.001	9	view →
BLCA	All	All	+0.668	<.001	8	view →
KIRC	All	All	+0.283	<.001	8	view →
CHOL	Male	All	+1.743	<.001	5	view →
STAD	Male	All	+0.495	.021	5	view →
LUAD	Male	All	+0.303	<.001	5	view →
HNSC	All	All	+0.266	.008	4	view →
ESCA	Female	All	+0.666	.015	1	view →
LUSC	All	All	+0.189	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

COG4–COAD

Open the COAD breakdown →