COG4

Across TCGA patient cohorts, COG4 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,307 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible COG4-associated proteins across cancer lineages are DHX38, EDC4, and DDX19A. Each is linked with COG4 in more than 8 cancer types. Because this analysis shows association rather than direction, both COG4-to-partner and partner-to-COG4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, COG4 versus DHX38 in HNSC, with a Pearson correlation of 0.29.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (COG4→partner) and Y-score (partner→COG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DHX38 →	+0.275	+0.604	<.001	.003	2	9
BRCA	EDC4 →	+0.227	+0.433	<.001	<.001	3	8
OV	DDX19A →	+0.311	+0.384	<.001	.001	3	6
BRCA	WWP2 →	+0.344	+0.507	<.001	<.001	3	6
OV	KARS1 →	+0.335	+0.761	<.001	<.001	3	6
LSCC	TERF2 →	+0.352	+0.468	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,307 associations by consensus.

COG4 vs DHX38 — HNSC

Explore this scatter interactively →