COG4

Across TCGA patient cohorts, COG4 protein abundance is significantly associated with the RNA expression of many other genes, with 12,469 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible COG4-associated genes across cancer lineages are COG3, DNAJC3, and GJB1. Each is linked with COG4 in more than 7 cancer types. Because this analysis shows association rather than direction, both COG4-to-partner and partner-to-COG4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, COG4 versus COG3 in OV, with a Pearson correlation of 0.48.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COG4→partner) and Y-score (partner→COG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	COG3 →	+0.559	+0.269	.001	<.001	3	8
BRCA	DNAJC3 →	+0.574	+0.272	.001	<.001	3	6
LUAD	GJB1 →	+1.379	+0.235	.001	.001	3	5
CCRCC	PARP4 →	+0.455	+0.243	<.001	<.001	3	5
OV	COG6 →	+0.470	+0.174	.001	<.001	3	5
LUAD	LNX2 →	+0.713	+0.233	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,469 associations by consensus.

COG4 vs COG3 — OV

Explore this scatter interactively →