COG4

Across TCGA patient cohorts, COG4 mutation is significantly associated with the RNA expression of many other genes, with 3,008 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COG4-associated genes across cancer lineages are CHEK1, NCAPD3, and RRM1. Each is linked with COG4 in more than 2 cancer types. Because this analysis shows association rather than direction, both COG4-to-partner and partner-to-COG4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHEK1 grouped by COG4-low versus COG4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COG4→partner) and Y-score (partner→COG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CHEK1 →	+0.498	+2.345	.009	.003	3	3
UCEC	NCAPD3 →	+0.658	+3.914	<.001	<.001	3	3
UCEC	RRM1 →	+0.744	+2.321	<.001	.001	3	3
UCEC	DNAJC7 →	+0.403	+2.947	.002	<.001	3	3
UCEC	DNAJC24 →	+0.436	+2.332	<.001	<.001	3	3
UCEC	CKAP5 →	+0.527	+2.807	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,008 associations by consensus.

CHEK1 by COG4 expression — UCEC

Explore this box plot interactively →