COG4

Across TCGA patient cohorts, COG4 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COG4-associated genes across cancer lineages are JNK2, p27_pT198, and Annexin-1. Each is linked with COG4 in more than 1 cancer types. Because this analysis shows association rather than direction, both COG4-to-partner and partner-to-COG4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by COG4-low versus COG4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COG4→partner) and Y-score (partner→COG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.233	+1.678	.002	.023	3	2
UCEC	p27_pT198 →	+0.117	+3.247	.004	<.001	3	2
UCEC	Annexin-1 →	+0.468	+2.341	.020	.019	3	2
SKCM	Snail →	-0.166	-2.987	.043	.035	3	1
UCEC	eIF4E →	+0.184	+2.087	.022	.005	3	1
UCEC	FoxM1 →	+0.223	+1.884	.024	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

JNK2 by COG4 expression — UCEC

Explore this box plot interactively →