COG4

Across TCGA cell cohorts, COG4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,486 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible COG4-associated GO terms across cancer lineages are mRNA export from nucleus, mRNA transport, and Regulation of organelle assembly. Each is linked with COG4 in more than 14 cancer types. Because this analysis shows association rather than direction, both COG4-to-partner and partner-to-COG4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mRNA export from nucleus grouped by COG4-low versus COG4-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (COG4→partner) and Y-score (partner→COG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	mRNA export from nucleus →	+0.097	+0.875	.006	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	mRNA transport →	+0.092	+0.691	.005	.005	3	15
LARGE_INTESTINE	Regulation of organelle assembly →	+0.038	+0.852	.001	<.001	3	14
URINARY_TRACT	Basolateral protein secretion →	+0.203	+0.763	<.001	.003	3	13
LARGE_INTESTINE	mRNA alternative polyadenylation →	+0.083	+0.795	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Establishment of RNA localization →	+0.098	+1.080	.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,486 associations by consensus.

mRNA export from nucleus by COG4 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →