COG4

Across TCGA cell cohorts, COG4 mutation is significantly associated with the mutation status of many other genes, with 1,569 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible COG4-associated genes across cancer lineages are IRGC, BCL11B, and CDH15. Each is linked with COG4 in more than 2 cancer types. Because this analysis shows association rather than direction, both COG4-to-partner and partner-to-COG4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IRGC grouped by COG4-low versus COG4-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COG4→partner) and Y-score (partner→COG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IRGC →	+3.894	+5.247	.001	.001	1	3
BLOOD_Lymphoma	BCL11B →	+3.731	+3.938	<.001	<.001	1	3
BLOOD_Lymphoma	CDH15 →	+3.731	+3.938	<.001	<.001	1	3
BLOOD_Lymphoma	DIAPH3 →	+3.731	+3.554	.003	.003	1	3
LARGE_INTESTINE	ZNF366 →	+4.744	+5.459	<.001	<.001	1	3
LARGE_INTESTINE	KDM4B →	+2.284	+3.925	.005	.005	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,569 associations by consensus.

IRGC by COG4 expression — BLOOD_Leukemia

Explore this box plot interactively →