COG3

Across TCGA patient cohorts, COG3 mutation is significantly associated with the RNA expression of many other genes, with 2,088 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COG3-associated genes across cancer lineages are MIR4418, RNA5SP463, and RN7SL508P. Each is linked with COG3 in more than 1 cancer types. Because this analysis shows association rather than direction, both COG3-to-partner and partner-to-COG3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4418 grouped by COG3-low versus COG3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COG3→partner) and Y-score (partner→COG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIR4418 →	+0.727	+4.308	<.001	.009	3	2
UCEC	RNA5SP463 →	+0.462	+1.630	<.001	.003	3	2
UCEC	RN7SL508P →	+0.130	+1.593	.009	.007	3	2
LUSC	MIRLET7A2 →	+0.357	+4.606	<.001	.006	3	2
LUSC	TUBAP4 →	+0.184	+3.992	<.001	.006	3	2
BRCA	MIR6807 →	+0.431	+3.692	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,088 associations by consensus.

MIR4418 by COG3 expression — COAD

Explore this box plot interactively →